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Aug 17, 2011 Stereospecific Nickel-Catalyzed Cross-Coupling Reactions Aug 18, 2015 有机化学里"traceless directing"是什么意思? - 知乎

meta-Selective olefination of fluoroarenes with alkynes

meta-Selective olefination of fluoroarenes with alkynes directing group strategy is only applicable to aromatics con- taining a group that can be easily derivatised. Scheme 1Comparison of the template approach and the traceless directing group relay strategy for the meta olefination of arenes. The use of carboxylic acids as traceless directing groups Alternatively, carboxylic acids have been employed as traceless directing groups that are easily removed after carboxylic acid-directed installation of the desired functionality. This review focuses on the development of this concept and its application to organic synthesis during the last decade.

A highly efficient and general protocol for traceless, directed C3-selective C-H borylation of indoles with [Ni(IMes)2] as the catalyst is reported. Activation and borylation of N-H bonds by [Ni(IMes)2] is essential to install a Bpin moiety at the N-position as a traceless directing group, which enables the C3-selective borylation of C-H bonds.

A highly efficient and general protocol for traceless, directed C3-selective C-H borylation of indoles with [Ni(IMes)2] as the catalyst is reported. Activation and borylation of N-H bonds by [Ni(IMes)2] is essential to install a Bpin moiety at the N-position as a traceless directing group, which enables the C3-selective borylation of C-H bonds. Directed Meta-Selective CH Bond Functionalizations In 2011, Larrosa and co-workers disclosed a method for formal meta-C H arylation using carboxylic acids as a traceless ortho-directing group (Scheme 8.43) with aryl iodides as coupling partners, which was compatible with a wide range of meta-substituents (Scheme 8.44). 84 Importantly, this tandem directed C H arylation/protodecarboxylation Cu(II)‐Mediated C−C/C−O Bond Formation via C−H/C−C Bond